Nature reviews the accelerating threat of antimicrobial resistance and highlights emerging strategies—including AI-driven antibiotic discovery, novel therapeutics and responsible antibiotic use—to preserve the effectiveness of existing antimicrobials.

In this episode of The Lancet Voice, Ramanan Laxminarayan, Founder of the One Health Trust and lead author of The Lancet Series on Sustainable Access to Antibiotics, discusses the current and future burden of antimicrobial resistance. The conversation explores antimicrobial stewardship, sustainable antibiotic access, innovation, and the coordinated global actions required to address one of the most pressing public health challenges.

This educational video from the U.S. Centers for Disease Control and Prevention (CDC) explains the fundamentals of antimicrobial resistance, its impact on healthcare, food production and the environment, and the strategies being implemented to address this growing public health challenge. It also outlines the role of healthcare professionals, policymakers and the general public in preventing the spread of resistance.

Antimicrobial resistance is one of the greatest challenges facing modern medicine. In this video, researchers from the University of Cambridge explain how AI-powered tools—including AlphaFold, Gemini and Co-Scientist—are accelerating the discovery of bacterial resistance mechanisms. By combining structural biology with artificial intelligence, processes that once required years can now be completed in minutes, opening new opportunities for antibiotic research.

In this TEDx talk, Katrina Sylvester explores antimicrobial resistance as one of the defining global health threats of our time. Through an accessible overview of the rise of multidrug-resistant pathogens, she highlights why the post-antibiotic era is no longer a distant possibility and emphasizes the collective responsibility needed to preserve the effectiveness of existing antibiotics.